By U. Veronesi (auth.), Prof. Dr. med. Hans Jörg Senn, Richard D. Gelber Ph.D., Prof. Dr. med. Aron Goldhirsch, Dr. med. Beat Thürlimann (eds.)
This quantity presents an up to date survey of present laboratory and, frequently, scientific learn at the diagnostic and cures in basic breast melanoma. The chapters derive from the invited specialist lectures awarded on the fifth foreign convention of fundamental Breast melanoma held in St. Gallen, Switzerland, in March 1995. The papers disguise correct matters resembling epidemiology and genetics in addition to the biology of breast melanoma, diagnosis of reaction and tumor markers, screening and remedy of DCIS, surgical procedure for early breast melanoma, radiotherapy as a part of fundamental administration, adjuvant systemic cytotoxic and endocrine remedies, and, for the 1st time, women's overall healthiness perceptions and breast melanoma. As at prior meetings, this one additionally closed with a world consensus at the fundamental remedy of breast melanoma, formulated by way of American, eu, and Australian specialists in quite a few therapy modalities and biostatics. those 1995 remedy options surround pratical judgements open air of scientific trials and destiny study questions.
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Extra resources for Adjuvant Therapy of Breast Cancer V
Carcinogenesis 16:39-52 Makino H, Ishizaka Y, Tsujimoto A, Nakamura T, Onda M, Sugimura T, Nagao M (1992) Rat p53 gene mutations in primary Zymbal gland tumors induced by 2amino-3-methylimidazo[4,5-f]quinoline, a food mutagen. Proc Natl Acad Sci USA 89:4850-4854 Matos EL, Thomas DB, Sobel N, Vuoto D (1991) Breast cancer in Argentina: casecontrol study with special reference to meat eating habits. Neoplasma 38:357-366 Messina MJ, Persky V, Setchell KDR, Barnes S (1994) Soy intake and cancer risk; a review of the in vitro and in vivo data.
Cancer Epidemiol Biomark Pre v 3:675-682 Layton DW, Bogen KT, Knize MG, Hatch FT, Johnson VM, Felton JS (1995) Cancer risk of heterocyclic amines in cooked foods: an analysis and implications for research. Carcinogenesis 16:39-52 Makino H, Ishizaka Y, Tsujimoto A, Nakamura T, Onda M, Sugimura T, Nagao M (1992) Rat p53 gene mutations in primary Zymbal gland tumors induced by 2amino-3-methylimidazo[4,5-f]quinoline, a food mutagen. Proc Natl Acad Sci USA 89:4850-4854 Matos EL, Thomas DB, Sobel N, Vuoto D (1991) Breast cancer in Argentina: casecontrol study with special reference to meat eating habits.
The ability of cancer cells to stick to endotheliUJp and move through the basement membranes at either the primary or metastatic site is clearly related to their potential to spread and kill their hosts. Cathepsin D is a protease,the concentration of which in a breast cancer specimen is known to be both hormonally modulatable and relevant to the outcome of the woman bearing that cancer (Rochefort et al. 1988; Spyratos et al. 1989; Tandon et al. 1990). Mammostatin, a negative regulator of breast cell growth and division, is known to be absent or diminished in breast cancer and to cycle with very high amplitude during the menstrual cycle (Wicha 1991).
Adjuvant Therapy of Breast Cancer V by U. Veronesi (auth.), Prof. Dr. med. Hans Jörg Senn, Richard D. Gelber Ph.D., Prof. Dr. med. Aron Goldhirsch, Dr. med. Beat Thürlimann (eds.)