By Ashutosh Tiwari, Bora Garipcan, Lokman Uzun
The ebook outlines first the significance of additional mobile Matrix (ECM), that is a typical floor for many of cells. within the following chapters the impact of organic, chemical, mechanical, and actual houses of surfaces in micro and nano-scale on stem cellphone habit are mentioned together with the mechanotransduction. Biomimetic and bioinspired techniques are highlighted for constructing microenvironment of a number of tissues, and floor engineering purposes are mentioned in tissue engineering, regenerative medication and diverse kind of biomaterials in a variety of chapters of the book.
This booklet brings jointly leading edge methodologies and methods followed within the examine and improvement of Advanced Surfaces in Stem phone Research. recognized around the world researchers planned topics including:
- Extracellular matrix proteins for stem cellphone fate
- The superficial mechanical and actual homes of matrix microenvironment as stem mobile destiny regulator
- Effects of mechanotransduction on stem phone behavior
- Modulation of stem cells habit via bioactive surfaces
- Influence of managed micro and nanoengineered surfaces on stem phone fate
- Nanostructured polymeric surfaces for stem cells
- Laser floor amendment concepts and stem cells applications
- Plasma polymer deposition: a flexible device for stem telephone research
- Application of bioreactor proposal and modeling thoughts in bone regeneration and augmentation treatments
- Substrates and surfaces for regulate of pluripotent stem telephone destiny and function
- Application of biopolymer-based, floor transformed units in transplant medication and tissue engineering
- Silk as a normal biopolymer for tissue engineering
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Extra info for Advanced Surfaces for Stem Cell Research
On the one hand, the design of substrates with synergistic effect in mechanical and physical properties with the biological and biochemical cues can control stem cell fate with more quality and accurate. On the other hand, with a more detailed understanding of biological microenvironments and mimic their structures can prevent since many of the diseases. So, alterations in superficial cues (such as physical and mechanical properties on the surfaces of substrates) could not only lead to aberrant growth or differentiation of stem cells but also provide a potential therapeutic target for regenerative medicine.
61]. 30 Advanced Surfaces for Stem Cell Research For example, created sharp topography duo to existence of Multiwall Carbon Nanotubes (MWCNT) in PLGA–MWCNT reduced platelet adhesion . According to microenvironment conditions, surface topographies can be fixed or vary, for instance with degradation or mechanical stimuli scaffold surface will be delaminated, such as intramuscular movements and body fluid/blood flow shear stress. Size, aspect ratio, and density of topography in surface of scaffolds are important parameters that prepared by following methods [69–72]: Polymer demixing, Colloidal-derived topographies, Dual-scale diameter topographies, Polymers including hot embossing, Nanoimprint lithography.
Et al. Activation of focal adhesion kinase enhances the adhesion and invasion of pancreatic cancer cells via extracellular signal-regulated kinase-1/2 signaling pathway activation. Mol. Cancer. 4, 37, 2005. L. Role of focal adhesion kinase in integrin signaling. Int. J. Biochem. Cell Biol. 29, 1085–96, 1997. H. Signalling pathways linking integrins with cell cycle progression. Matrix Biol. 34, 144–53, 2014. Coqueret O. New roles for p21 and p27 cell-cycle inhibitors: a function for each cell compartment?
Advanced Surfaces for Stem Cell Research by Ashutosh Tiwari, Bora Garipcan, Lokman Uzun