By C. L. Wellington, B. R. Leavitt (auth.), Prof. Y. Mizuno, Prof. D. B. Calne, Dr. R. Horowski, Prof. W. Poewe, Prof. P. Riederer, Prof. M. B. H. Youdim (eds.)
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Extra resources for Advances in Research on Neurodegeneration: Volume 7
Clin Neurol (Tokyo) 33: 491-496 Authors' address: Prof. N. jp Autosomal-dominantly inherited forms of Parkinson's disease T. Gasser Neurologische Klinik und Poliklinik, Klinikum GroBhadern, Ludwig-Maximilians-Universitat, Munich, Federal Republic of Germany Summary. Today, a genetic contribution to the etiology of Parkinson's disease (PD) is generally accepted, based on the demonstration of a familial aggregation of the disease, as demonstrated by several case-control and twinstudies. However, most cases of PD appear to be sporadic, and in the majority of those with a positive family history, no clear mendelian mode of inheritance can be established.
Recurrence risks are similar in siblings and offspring, compatible with autosomal dominant inheritance with reduced penetrance in the majority of cases, although other modes of inheritance in subsets of patients cannot be ruled out. , 1998). , 1997). Interestingly, in large autopsy series of individuals dying without clinical symptoms of PD, a mild cell loss in the substantia nigra and the presence of Lewy-bodies can be found in as many as 15% of cases, also supporting the assumption that sub- or preclinical PD (possibly indicating the presence of a common inherited trait) may be much more frequent than the clinical disease (Fearnley and Lees, 1991).
Am J Hum Genet 60: 588-596 Matsumine H, Yamamura Y, Hattori N, Kobayashi T, Kitada T, Yoritaka A, Mizuno Y (1998) A microdeletion of D6S305 in a family of autosomal recessive juvenile parkinsonism (PARK2). Genomics 49: 143-146 Mezey E, Dehejia A, Harta G, Papp MI, Polymeropoulos MH, Brownstein MJ (1998) Alpha synuclein in neurodegenerative disorders: murderer or accomplice? Nature Med 4: 755-757 Mori H, Kondo J, Ihara Y (1987) Ubiquitin is a component of paired helical filaments in Alzheimer's disease.
Advances in Research on Neurodegeneration: Volume 7 by C. L. Wellington, B. R. Leavitt (auth.), Prof. Y. Mizuno, Prof. D. B. Calne, Dr. R. Horowski, Prof. W. Poewe, Prof. P. Riederer, Prof. M. B. H. Youdim (eds.)