By Nicolle Sitte, Thomas von Zglinicki (auth.), Thomas von Zglinicki (eds.)
During the final forty years, the research of the organic foundation of getting older has improved vastly, and it has now develop into an self reliant and first rate box of analysis and study. the fundamental reason for getting older is molecular harm that slowly overwhelms mobile and organismic protection, fix and upkeep structures. lately, a wealth of hugely subtle examine has remodeled this concept from a reputable speculation not just to a huge thought, yet primarily to accredited wisdom. getting older on the Molecular point examines the most important components during this transformation.
Bringing jointly contributions from a world group of authors, this quantity might be of curiosity to graduates and postgraduates within the fields of drugs and nursing, researchers of other elements of biogerontology and people within the pharmaceutical, cosmeceutical, nutraceutical and health-care industry.
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Extra info for Aging at the Molecular Level
Protein oxidation. Ann NY Acad Sci. 899: 191-208. 35. Oliver CN, Ahn BW, Moerman EJ, Goldstein S, Stadtman ER (1987). Age-related changes in oxidized proteins. J Bioi Chern. 262: 5488-91. OXIDATIVE DAMAGE TO PROTEINS 45 36. Agarwal S, Sohal RS (1994). Aging and proteolysis of oxidized prott;ins. Arch Biochem Biophys. 309: 24--8. 37. Agarwal S, Sohal RS (1994). Ageing and protein oxidative damage. Mech Ageing Dev. 75: 11-19. 38. Agarwal S, Sohal RS (1996). Relationship between susceptibility to protein oxidation, aging, and maximum life span potential of different species.
DNA repair disorders in man are almost always associated with neurological disorders thus substantiating this notion. Further work is required to monitor DNA repair of oxidative DNA damage in the elderly population in order to get more evidence for the role of DNA repair for longevity and, if applicable, to identify individuals prone to dementia prior to onset for early administration of preventive measures. OXIDATIVE DNA DAMAGE AND REPAIR- IMPLICATIONS FOR AGING 23 References 1. Lindahl T (1993).
A novel human DNA glycosylase that removes oxidative DNA damage and is homologous to Escherichia coli endonuclease VIII. DNA Repair (Arnst) 1: 517-29. 41. Rosenquist TA, Zaika E, Fernandes AS, Zharkov DO, Miller H, Grollman AP (2003). The novel DNA glycosylase, NEILl, protects mammalian cells from radiation-mediated cell death. DNA Repair (Arnst) 2: 581-91. Oxidative Damage to Proteins Nicolle Sitte Department of Anaesthesiology and Critical Care Medicine, CHARITE- University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany Introduction Protein oxidation in vivo is a natural consequence of aerobic life.
Aging at the Molecular Level by Nicolle Sitte, Thomas von Zglinicki (auth.), Thomas von Zglinicki (eds.)