By M. A. D. van Zoelen, A. Achouiti, T. van der Poll (auth.), Prof. Jean-Louis Vincent (eds.)
The Annual replace compiles the newest advancements in experimental and medical learn and perform in a single entire reference booklet. The chapters are written via good well-known specialists within the box of extensive care and emergency drugs. it's addressed to every body all for inner drugs, anesthesia, surgical procedure, pediatrics, in depth care and emergency medicine.
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Extra info for Annual Update in Intensive Care and Emergency Medicine 2011
While interpreting the results from preclinical investigations, one has to keep in mind that a careful balance between the inflammatory and anti-inflammatory response is vital in order to survive or recover from a severe infection. The observation that lack of RAGE is of benefit in one pneumonia model and detrimental in another, clearly adds to the notion that the way in which RAGE mediates host defense against different pathogens relies on distinct mechanisms. It would be highly interesting to evaluate whether RAGE can directly bind to, become activated, and mount a first immune reaction after ligation with specific PAMPs.
46. 47. 48. 49. 50. necrosis factor-alpha in the gut and systemic anti-inflammatory activity of SR 141716 (rimonabant) in rodents. Br J Pharmacol 140: 115 – 122 Malfitano AM, Laezza C, Pisanti S, Gazzerro P, Bifulco M (2008) Rimonabant (SR141716) exerts anti-proliferative and immunomodulatory effects in human peripheral blood mononuclear cells. Br J Pharmacol 153: 1003 – 1010 Greenhough A, Patsos HA, Williams AC, Paraskeva C (2007) The cannabinoid delta(9)-tetrahydrocannabinol inhibits RAS-MAPK and PI3K-AKT survival signalling and induces BAD-mediated apoptosis in colorectal cancer cells.
Cataldegirmen G, Zeng S, Feirt N, et al (2005) RAGE limits regeneration after massive liver injury by coordinated suppression of TNF-alpha and NF-kappaB. J Exp Med 201: 473 – 484 12. Park L, Raman KG, Lee KJ, et al (1998) Suppression of accelerated diabetic atherosclerosis by the soluble receptor for advanced glycation endproducts. Nat Med 4: 1025 – 1031 13. Schmidt AM, Yan SD, Yan SF, Stern DM (2001) The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses.
Annual Update in Intensive Care and Emergency Medicine 2011 by M. A. D. van Zoelen, A. Achouiti, T. van der Poll (auth.), Prof. Jean-Louis Vincent (eds.)